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Furthermore, pharmacotherapeutic trials targeting monoaminergic systemssuch as SSRIs and bupropionhave shown modest efficacy in reducing depressive symptoms in alcoholics, though their benefits are often overshadowed by high placebo response rates and relapse risk (Agabio et al

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As the observed branching morphogenesis would be expected to require coordinated proliferation and migration of cells, the dimeric macrocycles could fulfill the function of regenerative drugs for the repair of tissue damage or for other therapeutic uses