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After absorption, iron ions are oxidized by ceruloplasmin in the blood to trivalent iron ions, which then bind to transferrin receptor and enter the cells in the form of pinocytosis for hematopoietic cells

when a xenobiotic compound binds to and activates the receptor, the complex is translocated to the nucleus, where it binds to the enhancer regions of various biotransformation enzymes, promoting increased expression of P450 enzymes via transcription