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Une prsence au cur des cellules

Primary Research Areas Triple GIP/GLP-1/glucagon receptor agonism: Mechanistic studies dissecting receptor pharmacology, biased signaling and downstream pathways triggered by combined incretin and glucagon receptor activation

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(99) demonstrated that Gpx4 expressed in myeloid cells plays a crucial role in lipid peroxidation, inflammasome activation, and release of DAMPs in the setting of sepsis, with Gpx4 deletion leading to increased lethality in sepsis conditions