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However, in a subanalysis of participants with low vitamin B 12 status at baseline (n= 101), the B-vitamin supplementation slowed the decline in bone mineral density (total hip and femoral neck but not lumbar spine) (116)

Signs to look out for include fatigue and lethargy, depression, irritability, headaches, difficulty with balance, decreased cognitive function, constipation, sore or swollen tongue, heart palpitations, mouth ulcers, pins and needles and changes to vision

Even modest weight loss of around 5% can make a substantial difference to PCOS symptoms