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The supplement dose (typically 500 to 1,000 mcg) is far above the RDA because oral absorption of B12 is limited to roughly 1 to 2% of the dose at high intakes, via passive diffusion

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Consider the case of megaloblastic anemia where vitamin B deficiency causes the production of unusually big and inefficient red blood cells

With the exception of the proposed payment rate for brachytherapy source C2645 (Brachytherapy planar source, palladium-103, per square millimeter) and the proposed payment rates for low-volume brachytherapy APCs discussed in section III.D