It can result from increased production of ROS and reduced levels of antioxidants
Wang XX, Myakala K, Libby AB, Krawczyk E, Panov J, Jones BA, et al
Promoting Healthy Skin, Hair, and Nails with B12 Vitamin B12s benefits extend to improving the appearance and health of your skin, hair, and nails by playing a key role in cell production and renewal

calculation of individual heat flows 4.2.1 Radiant heat transfer Absolute temperatures: T_ogr = 12 273.15 = 285.15 K T_l = -4 273.15 = 269.15 K Radiant heat exchange: q_radiant = 5.67-10- 0.88 (285.15 269.15 ) 69.5 W/m 4.2.2 Convective heat exchange Heat transfer coefficient: = 3.14 3.55-w = 3.14 3.55-0.25 = 4.03 W/(m-K) Heat load: q_k = 4.03 (12 (-4)) = 4.03 16 = 64.5 W/m 4.2.3 Condensation load q_condens = 0.7 (/100) (t_v t_l) = 0.7 0.55 16 6.2 W/m 4.2.4 Heat conduction through the slab Lets use the enlarged value for the construction with insulation: q_pl = 8 W/m 4.2.5 Light absorption by ice Heat flux density: q_osv = (P_osv _pogl) / A = (22000 0.45) / 1800 5.5 W/m 4.2.6 Thermal effect of one pour (average per hour) Water mass: m = A h = 1000 1800 0.0006 = 1080 kg Thermal effect: Q_hall = m [ c_v-(t_vz 0) r c_l-|t_l| ] Substitution: c_v = 4200 J/(kg-K) c_l = 2100 J/(kg-K) r = 334000 J/kg t = 50 K Q_hall = 1080 [4200-50 334000 2100-4] = 5.96-10 J Conversion to kWh considering the interval between pours of 4 hours: Q_zal = 5.96-10 / (4 3.6-10 ) 42 kW Per m: q_exp = 42-1000 / 1800 23.3 W/m 4.3

where the form is reported, it is stated in this paper