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A study conducted in 2016 thus came to the following conclusion: If we had restricted the treatment of symptomatic patients to patients with both low serum levels and elevated metabolite levels, 63% of patients who responded well to the therapy would not have received treatment [] Only 16% of patients with good clinical improvement from vitamin B12 therapy had low serum levels and 54% of patients with good clinical improvement from vitamin B12 therapy had serum levels higher than 300 pg/mL. Some experts thus advise high-dose B12 treatment to treat all known nervous symptoms associated with B12 deficiency

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Anjum NA, Singh N, Singh MK, Shah ZA, Duarte AC, Pereira E, Ahmad I (2013) Single-bilayer graphene oxide sheet tolerance and glutathione redox system significance assessment in faba bean (Vicia faba L.)

Vestibular Cohorts : Small studies report 3050% reduction in Dizziness Handicap Inventory (DHI) scores after 3 months of B12 in patients with chronic dizziness and low-normal levels