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However, they also have limitations: many are unstable in the gut, so they are often given by injection, and some have limited human data outside of specific indications

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doi: 10.1007/978-94-007-2199-9_1 62

However, as of the publication date of this article, no formal FDA reclassification has been finalized

Typical workflows include fibroblast or keratinocyte culture assays for gene expression and proliferation readouts, accelerated stability studies in candidate base formulations, and side-by-side comparison against alternative peptide chemistries