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[DOI] [PMC free article] [PubMed] [Google Scholar] 51.Major J.M., Laughlin G.A., Kritz-Silverstein D., Wingard D.L., Barrett-Connor E

Calculations of key parameters of the mitochondrial function were performed, consisting of basal respiration (BR, OCR initial OCR rot/AA ), ATP production (ATP, OCR initial - OCR oligo ), proton leak (PL, OCR oligo OCR rot/AA ), maximal respiration (MR, OCR FCCP OCR rot/AA ), spare respiratory capacity (SRC, OCR FCCP - OCR initial ), spare respiratory capacity [%] (SRCP, MR/BR*100), non-mitochondrial respiration rate (NMRR, OCR rot/AA ), and coupling efficiency [%] (CE, ATP/BR*100)

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Karas L, Asif M, Chun V, Khan FA

Figure 2 4.1 High expression of all three key SSP enzymes: PHGDH, PSAT1 and PSPH 4.1.1 Non-small cell lung cancer In non-small cell lung cancer (NSCLC), the expression of PHGDH, the rate-limiting enzyme of the SSP, is significantly higher in tumor tissues than in adjacent normal tissues, and is positively correlated with TNM stage