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Figure 5: Comparative stimulation of pulsatile GH release and IGF-1 concentrations by GHRH vs GHRP-2 in healthy older men and women after 30 days of treatment

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Interestingly, the cavity corresponding to Cavity II in the ghrelin receptor is closed in the motilin receptor, and this closure is primarily attributed to Phe173 4.60 and Leu249 5.40 in the motilin receptor, corresponding to Ile178 4.60 and Val214 5.40 in the ghrelin receptor (Figures 4B,C)