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Broadly, mitochondrial-driven diseases can be classified into two categories: i) primary mitochondrial diseases, which stem from direct genetic mutations of mtDNA or nDNA encoding for proteins expressed in the mitochondria and ii) mitochondrial dysfunction associated with complex diseases, observed in systemic conditions such as diabetes (Yoon et al., 2011 February 1), ischemia reperfusion injury (Figure 1)

Earlier studies have shown that in healthy volunteers, daily doses of VitC exceeding 500 mg tend to decrease its bioavailability

Understanding muscle dysfunction in chronic fatigue syndrome

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Further studies are needed to elucidate the mechanisms underlying these important potential differences