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Targeting active molecules to the mitochondria is likely to improve their effectiveness against oxidative insult and hence be beneficial for FRDA patients due to reduced off-target therapy, increased specificity and lower therapeutic dosage required of the targeted chelator (Reelfs, et al., 2019

Inhibition of Schistosoma mansoni thioredoxin glutathione reductase by auranofin: Structural and kinetic aspects

J Exp Bot 49(329):18951908

Accelerating skin regeneration and wound healing by controlled ROS from photodynamic treatment

The protocol first involved collating various kinetic values from literature, and assigning each value a weight to represent their plausibility, based on the organism, enzyme and conditions under which the kinetic parameter was measured