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Beyond these targeted movements, remember the core principles of 'smart relief.' Its about moving *better*, not necessarily resting completely

DOP are among the most common secondary OPs [5], and are closely associated with diabetes

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Although studies with cereblon-based PROTACs are still scarce, it is expected that long-term clinical use of this type of degrader could lead to the emergence of mutations that prevent PROTAC from binding to cereblon, thus preventing poly-ubiquitination of the target protein