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In addition, NLRP3 inflammasome activation can disrupt tight junction proteins between EC, resulting in increased vascular permeability ( Figure 6 )

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If it breaks down, things can leak through

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Ne G., Zaffagnini M., Trost P

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The cysteinyl thiol is a potent reducing agent, making GSH the most abundant antioxidant intracellular small molecule thiol

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