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The thermosensitive injectable celecoxib-loaded chitosan hydrogel for repairing postoperative intervertebral disc defect

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doi: 10.1038/s41467-017-00658-6 95 FarkhondehTSamarghandianSShahriAMPSaminiF

When B12 is low, or when folate-related enzymes are less active, the body may shift toward the betaine (BHMT) pathway to maintain methionine and SAMe

The pharmacology in animal studies and early human studies supported this design: AOD-9604 stimulates lipolysis and inhibits lipogenesis through activation of beta-3 adrenergic receptors in adipose tissue, without producing the IGF-1 elevation or insulin resistance signal that exogenous GH produces