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Under hypoxia or mitochondrial dysfunction, -KG can be converted to citrate by Isocitrate dehydrogenase (IDH 2) catalyzed carboxylation reaction, which is used for the synthesis of amino acids and fatty acids and the production of reducing agent NADPH

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NAC also has a high affinity for lung tissue, providing nutritional support to lung cells

doi: 10.1177/1352458519872652 26 RezaeizadehHMohammadpourZBitarafanSHarirchianMHGhadimiMHomayonIA

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