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In a dose proportionality study involving multiple CMI doses, steady-state plasma concentrations (CSS) and area-under-plasma-concentration-time curves (AUC) of CMI and CMI's major active metabolite, desmethylclomipramine (DMI), were not proportional to dose over the ranges evaluated, i.e., between 25 to 100 mg/day and between 25 to 150 mg/day, although CSS and AUC are approximately linearly related to dose between 100 to 150 mg/day

doi: 10.1016/j.ultsonch.2021.105686

Suitable during intense exercise

The Fix: Stick with Bacteriostatic Reconstitution Water (bac) unless your specific, single-use protocol absolutely requires sterile water

PMID 21284704