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This data suggests that 5-OP accumulation to 12-fold higher levels causes only a mild stress to the cell through multiple pathways which cumulatively leads to the growth defect in oxp1 strain

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Bevacizumab plus capecitabine versus capecitabine alone in elderly patients with previously untreated metastatic colorectal cancer (AVEX): an open-label, randomised phase 3 trial

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